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So, you've got your test results back, but what does it all mean? Let's break it down. For **IHC**, a score of 0 or 1+ indicates a *HER2-negative* result. This means your cancer cells don't have an excess of the HER2 protein, so the cancer isn't driven by HER2. A score of 3+ indicates a *HER2-positive* result, which means your cancer has an overabundance of the HER2 protein. You're likely a candidate for HER2-targeted therapy. The 2+ result is trickier, it’s *equivocal* and requires further testing with ISH to confirm your HER2 status. Now, with **ISH**, if the test shows *HER2 gene amplification*, your cancer is considered HER2-positive, regardless of the IHC score. If there's no amplification, your cancer is HER2-negative. So, understanding these results helps you and your doctor make informed decisions about your treatment plan. The HER2 status is a key factor, it determines the best course of action. It's important to discuss the results with your oncologist, they will explain the findings, and answer all your questions.
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