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So, what does it actually mean when a breast cancer is ER-positive? Basically, it means that the cancer cells have **receptors for estrogen**. These receptors are like little docking stations on the surface of the cancer cells. Estrogen, a hormone that fuels the growth of some breast cancers, attaches to these receptors. When estrogen docks, it sends signals to the cancer cells, telling them to grow and divide. That's why it's super crucial to understand the role of estrogen in this type of cancer. It’s like the fuel that keeps the fire burning, so to speak.