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Given that the HER2 protein promotes cancer cell growth in triple-positive breast cancer, therapies that target HER2 are critical. *These treatments* work by blocking the HER2 protein, preventing it from signaling cancer cells to grow and divide. ***Trastuzumab*** (Herceptin) is a well-known HER2-targeted therapy that binds to the HER2 receptor on cancer cells, flagging them for destruction by the immune system. Pertuzumab is another HER2-targeted antibody that works in conjunction with trastuzumab to provide a more comprehensive blockade of the HER2 pathway. Another option is *ado-trastuzumab emtansine* (T-DM1), which combines trastuzumab with a chemotherapy drug, delivering the chemotherapy directly to the cancer cells. More recently, *fam-trastuzumab deruxtecan-nxki* (Enhertu) has shown promising results in patients who have progressed on other HER2-targeted therapies. These treatments can cause side effects, so regular monitoring is essential. HER2-targeted therapies have significantly improved outcomes for patients with HER2-positive breast cancer. They are often used in combination with other treatments, such as chemotherapy and hormone therapy, to provide a multi-pronged attack on the cancer cells.
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