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**Step 1: Binding (gp120's Role)**. The HIV virus finds a target cell, which is typically a **CD4+ T cell** (a type of immune cell) or a macrophage. This is because these cells have the **CD4 receptor** on their surface. **Gp120 on the virus binds to the CD4 receptor**. But that's not enough; it's like needing two keys to unlock a door. Gp120 then undergoes a conformational change (a change in its shape), allowing it to also bind to a **co-receptor**, either **CCR5 or CXCR4**, which are also found on the surface of the target cell.
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