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TNBC stands out from other breast cancers because of its biology. The absence of hormone receptors means that hormonal therapies like tamoxifen or aromatase inhibitors, which are effective for other breast cancers, don't work for TNBC. Additionally, treatments targeting HER2, such as trastuzumab, are also ineffective since TNBC cells lack the HER2 protein. This limited range of treatment options often makes chemotherapy the primary treatment approach. The aggressive nature of TNBC, coupled with the lack of targeted therapies, means that it tends to have a poorer prognosis compared to other breast cancer subtypes, especially if not caught early. However, this is also an area of active research. Scientists are working hard to develop new therapies, including immunotherapies and targeted drugs, that can effectively treat TNBC. These new approaches are showing promise and are improving outcomes for those diagnosed with this challenging type of cancer.
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