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Getting a HER2 test is a standard part of breast cancer diagnosis, and it is usually done on a sample of tissue taken during a biopsy or surgery. This test gives doctors crucial information to determine the most effective treatment plan for your specific type of breast cancer. If the cancer is HER2-positive, then your doctor might recommend drugs specifically designed to target the HER2 protein. If your cancer is HER2-negative, then these drugs won't be as effective, so the doctors will consider other treatment options. The HER2 testing allows for a more personalized approach. It ensures you receive the most effective treatment for your unique situation. There are two main methods to determine the HER2 status: immunohistochemistry (IHC) and in-situ hybridization (ISH). IHC measures the amount of HER2 protein on the cancer cells' surface, giving a score from 0 to 3+. ISH looks at the number of HER2 genes in the cells, detecting if there's gene amplification.
